Thrombin drives tumorigenesis in colitis-associated colon cancer

The established association between inflammatory bowel disease and colorectal cancer underscores the importance of inflammation in colon cancer development. Based on evidence that hemostatic proteases are powerful modifiers of both inflammatory pathologies and tumor biology, gene-targeted mice carry...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Turpin, Brian, Miller, Whitney, Rosenfeldt, Leah, Kombrinck, Keith, Flick, Matthew J., Steinbrecher, Kris A., Harmel-Laws, Eleana, Mullins, Eric S., Shaw, Maureen, Witte, David P., Revenko, Alexey, Monia, Brett, Palumbo, Joseph S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288815/
https://ncbi.nlm.nih.gov/pubmed/24710407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3276
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