Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen

Thrombin-mediated proteolysis is a major determinant of metastasis, but is not universally important for primary tumor growth. Here, we report that colorectal adenocarcinoma represents one important exception whereby thrombin-mediated functions support both primary tumor growth and metastasis. In co...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Res
Egile Nagusiak: Adams, Gregory N., Rosenfeldt, Leah, Frederick, Malinda, Miller, Whitney, Waltz, Dusty, Kombrinck, Keith, McElhinney, Kathryn E., Flick, Matthew J., Monia, Brett P., Revenko, Alexey S., Palumbo, Joseph S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809049/
https://ncbi.nlm.nih.gov/pubmed/26238780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0964
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