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Protease activated receptor-1 impedes prostate and intestinal tumor progression in mice

BACKGROUND: Multiple studies have implicated Protease Activated Receptor-1 (PAR-1), a G-protein coupled receptor activated by proteolytic cleavage of its N-terminus, as one target coupling thrombin-mediated proteolysis to tumor progression. OBJECTIVE: We analyzed the role of PAR-1 in the setting of...

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Detalhes bibliográficos
Publicado no:J Thromb Haemost
Main Authors: Adams, Gregory N., Sharma, Bal Krishan, Rosenfeldt, Leah, Frederick, Malinda, Flick, Matthew J., Witte, David P., Mosnier, Laurent O., Harmel-Laws, Eleana, Steinbrecher, Kris A., Palumbo, Joseph S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214773/
https://ncbi.nlm.nih.gov/pubmed/30152921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14277
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