PDE-4 Inhibition Rescues Aberrant Synaptic Plasticity in Drosophila and Mouse Models of Fragile X Syndrome

Fragile X syndrome (FXS) is the leading cause of both intellectual disability and autism resulting from a single gene mutation. Previously, we characterized cognitive impairments and brain structural defects in a Drosophila model of FXS and demonstrated that these impairments were rescued by treatme...

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Argitaratua izan da:J Neurosci
Egile Nagusiak: Choi, Catherine H., Schoenfeld, Brian P., Weisz, Eliana D., Bell, Aaron J., Chambers, Daniel B., Hinchey, Joseph, Choi, Richard J., Hinchey, Paul, Kollaros, Maria, Gertner, Michael J., Ferrick, Neal J., Terlizzi, Allison M., Yohn, Nicole, Koenigsberg, Eric, Liebelt, David A., Zukin, R. Suzanne, Woo, Newton H., Tranfaglia, Michael R., Louneva, Natalia, Arnold, Steven E., Siegel, Steven J., Bolduc, Francois V., McDonald, Thomas V., Jongens, Thomas A., McBride, Sean M. J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society for Neuroscience 2015
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Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287155/
https://ncbi.nlm.nih.gov/pubmed/25568131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1356-12.2015
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