PDE-4 Inhibition Rescues Aberrant Synaptic Plasticity in Drosophila and Mouse Models of Fragile X Syndrome

Fragile X syndrome (FXS) is the leading cause of both intellectual disability and autism resulting from a single gene mutation. Previously, we characterized cognitive impairments and brain structural defects in a Drosophila model of FXS and demonstrated that these impairments were rescued by treatme...

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Publicat a:J Neurosci
Autors principals: Choi, Catherine H., Schoenfeld, Brian P., Weisz, Eliana D., Bell, Aaron J., Chambers, Daniel B., Hinchey, Joseph, Choi, Richard J., Hinchey, Paul, Kollaros, Maria, Gertner, Michael J., Ferrick, Neal J., Terlizzi, Allison M., Yohn, Nicole, Koenigsberg, Eric, Liebelt, David A., Zukin, R. Suzanne, Woo, Newton H., Tranfaglia, Michael R., Louneva, Natalia, Arnold, Steven E., Siegel, Steven J., Bolduc, Francois V., McDonald, Thomas V., Jongens, Thomas A., McBride, Sean M. J.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287155/
https://ncbi.nlm.nih.gov/pubmed/25568131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1356-12.2015
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