Pharmacological reversal of synaptic plasticity deficits in the mouse model of Fragile X syndrome by group II mGluR antagonist or lithium treatment

Fragile X syndrome is the leading single gene cause of intellectual disabilities. Treatment of a Drosophila model of Fragile X syndrome with metabotropic glutamate receptor (mGluR) antagonists or lithium rescues social and cognitive impairments. A hallmark feature of the Fragile X mouse model is enh...

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Bibliografiset tiedot
Päätekijät: Choi, Catherine H., Schoenfeld, Brian P., Bell, Aaron J., Hinchey, Paul, Kollaros, Maria, Gertner, Michael J., Woo, Newton H., Tranfaglia, Michael R., Bear, Mark F., Zukin, R. Suzanne, McDonald, Thomas V., Jongens, Thomas A., McBride, Sean M. J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050427/
https://ncbi.nlm.nih.gov/pubmed/21078304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2010.11.032
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