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PDE-4 Inhibition Rescues Aberrant Synaptic Plasticity in Drosophila and Mouse Models of Fragile X Syndrome

Fragile X syndrome (FXS) is the leading cause of both intellectual disability and autism resulting from a single gene mutation. Previously, we characterized cognitive impairments and brain structural defects in a Drosophila model of FXS and demonstrated that these impairments were rescued by treatme...

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書誌詳細
出版年:J Neurosci
主要な著者: Choi, Catherine H., Schoenfeld, Brian P., Weisz, Eliana D., Bell, Aaron J., Chambers, Daniel B., Hinchey, Joseph, Choi, Richard J., Hinchey, Paul, Kollaros, Maria, Gertner, Michael J., Ferrick, Neal J., Terlizzi, Allison M., Yohn, Nicole, Koenigsberg, Eric, Liebelt, David A., Zukin, R. Suzanne, Woo, Newton H., Tranfaglia, Michael R., Louneva, Natalia, Arnold, Steven E., Siegel, Steven J., Bolduc, Francois V., McDonald, Thomas V., Jongens, Thomas A., McBride, Sean M. J.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287155/
https://ncbi.nlm.nih.gov/pubmed/25568131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1356-12.2015
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