Pharmacological and Genetic Reversal of Age-Dependent Cognitive Deficits Attributable to Decreased presenilin Function

Alzheimer's disease (AD) is the leading cause of cognitive loss and neurodegeneration in the developed world. Although its genetic and environmental causes are not generally known, familial forms of the disease (FAD) are attributable to mutations in a single copy of the Presenilin (PS) and amyl...

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Main Authors: McBride, Sean M. J., Choi, Catherine H., Schoenfeld, Brian P., Bell, Aaron J., Liebelt, David A., Ferreiro, David, Choi, Richard J., Hinchey, Paul, Kollaros, Maria, Terlizzi, Allison M., Ferrick, Neal J., Koenigsberg, Eric, Rudominer, Rebecca L., Sumida, Ai, Chiorean, Stephanie, Siwicki, Kathleen K., Nguyen, Hanh T., Fortini, Mark E., McDonald, Thomas V., Jongens, Thomas A.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917645/
https://ncbi.nlm.nih.gov/pubmed/20631179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1017-10.2010
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