Age-dependent cognitive impairment in a Drosophila Fragile X model and its pharmacological rescue

Fragile X syndrome afflicts 1 in 2,500 individuals and is the leading heritable cause of mental retardation worldwide. The overriding clinical manifestation of this disease is mild to severe cognitive impairment. Age-dependent cognitive decline has been identified in Fragile X patients, although it...

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Hauptverfasser: Choi, Catherine H., McBride, Sean M. J., Schoenfeld, Brian P., Liebelt, David A., Ferreiro, David, Ferrick, Neal J., Hinchey, Paul, Kollaros, Maria, Rudominer, Rebecca L., Terlizzi, Allison M., Koenigsberg, Eric, Wang, Yan, Sumida, Ai, Nguyen, Hanh T., Bell, Aaron J., McDonald, Thomas V., Jongens, Thomas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866528/
https://ncbi.nlm.nih.gov/pubmed/20039205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10522-009-9259-6
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