Pharmacological reversal of synaptic plasticity deficits in the mouse model of Fragile X syndrome by group II mGluR antagonist or lithium treatment

Fragile X syndrome is the leading single gene cause of intellectual disabilities. Treatment of a Drosophila model of Fragile X syndrome with metabotropic glutamate receptor (mGluR) antagonists or lithium rescues social and cognitive impairments. A hallmark feature of the Fragile X mouse model is enh...

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Hlavní autoři: Choi, Catherine H., Schoenfeld, Brian P., Bell, Aaron J., Hinchey, Paul, Kollaros, Maria, Gertner, Michael J., Woo, Newton H., Tranfaglia, Michael R., Bear, Mark F., Zukin, R. Suzanne, McDonald, Thomas V., Jongens, Thomas A., McBride, Sean M. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050427/
https://ncbi.nlm.nih.gov/pubmed/21078304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2010.11.032
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