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Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design
PI3Kα remains an attractive target for the development of anticancer targeted therapy. A number of p110α crystal structures in complex with the nSH2-iSH2 fragment of p85 regulatory subunit have been reported, including a few small molecule co-crystal structures, but the utilization of this crystal f...
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| Udgivet i: | Protein Sci |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BlackWell Publishing Ltd
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4286995/ https://ncbi.nlm.nih.gov/pubmed/25043846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2517 |
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