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P110α and P110δ catalytic subunits of PI3 kinase regulate lysophosphatidylcholine-induced TRPC6 externalization

Lipid oxidation products, including lysophosphatidylcholine (lysoPC) inhibit endothelial cell (EC) migration in vitro and impair EC healing of arterial injuries in vivo, in part by activating phosphatidylinositol 3-kinase (PI3K), which increases the externalization of canonical transient receptor po...

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Bibliographic Details
Published in:Am J Physiol Cell Physiol
Main Authors: Chaudhuri, Pinaki, Smith, Andrew H., Putta, Priya, Graham, Linda M., Rosenbaum, Michael A.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163572/
https://ncbi.nlm.nih.gov/pubmed/33625929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00425.2020
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