Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation

Lipid oxidation products, including lysophosphatidylcholine (lysoPC), activate canonical transient receptor potential 6 (TRPC6) channels leading to inhibition of endothelial cell (EC) migration in vitro and delayed EC healing of arterial injuries in vivo. The precise mechanism through which lysoPC a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chaudhuri, Pinaki, Rosenbaum, Michael A., Sinharoy, Pritam, Damron, Derek S., Birnbaumer, Lutz, Graham, Linda M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776520/
https://ncbi.nlm.nih.gov/pubmed/26858457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600371113
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