The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer

BACKGROUND: PI3K/AKT is a vital signaling pathway in humans. Recently, several PI3K/AKT inhibitors were reported to have the ability to reverse cancer multidrug resistance (MDR); however, specific targets in the PI3K/AKT pathways and the mechanisms associated with MDR have not been found because man...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Zhang, Lei, Li, Yidong, Wang, Qianchao, Chen, Zhuo, Li, Xiaoyun, Wu, Zhuoxun, Hu, Chaohua, Liao, Dan, Zhang, Wei, Chen, Zhe-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966863/
https://ncbi.nlm.nih.gov/pubmed/31952518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-019-1112-1
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