Selective reversal of BCRP-mediated MDR by VEGFR-2 inhibitor ZM323881

The expression of breast cancer resistant protein (BCRP) in lung cancer is correlated with development of multidrug resistance (MDR) and therefore leads to lower response to chemotherapy. ZM323881, a previously developed selective VEGFR-2 inhibitor, was found to have inhibitory effects on BCRP-media...

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Vydáno v:Biochem Pharmacol
Hlavní autoři: Zhang, Yun-Kai, Zhang, Xiao-Yu, Zhang, Guan-Nan, Wang, Yi-Jun, Xu, Huizhong, Zhang, Dongmei, Shukla, Suneet, Liu, Lili, Yang, Dong-Hua, Ambudkar, Suresh V., Chen, Zhe-Sheng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841404/
https://ncbi.nlm.nih.gov/pubmed/28242251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.02.019
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