HO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer

STAT3 is well corroborated preclinically as a cancer therapeutic target, but tractable translational strategies for its blockade by small molecule inhibitors have remained elusive. In this study, we report the development of a novel class of bifunctional STAT3 inhibitors, based on conjugation of a d...

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Détails bibliographiques
Publié dans:Cancer Res
Auteurs principaux: Rath, Kellie S., Naidu, Shan K., Lata, Pushpa, Bid, Hemant K., Rivera, Brian K., McCann, Georgia A., Tierney, Brent J., ElNaggar, Adam C., Bravo, Veronica, Leone, Gustavo, Houghton, Peter, Hideg, Kálmán, Kuppusamy, Periannan, Cohn, David E., Selvendiran, Karuppaiyah
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286190/
https://ncbi.nlm.nih.gov/pubmed/24590057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2433
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