HO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer

STAT3 is well corroborated preclinically as a cancer therapeutic target, but tractable translational strategies for its blockade by small molecule inhibitors have remained elusive. In this study, we report the development of a novel class of bifunctional STAT3 inhibitors, based on conjugation of a d...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Rath, Kellie S., Naidu, Shan K., Lata, Pushpa, Bid, Hemant K., Rivera, Brian K., McCann, Georgia A., Tierney, Brent J., ElNaggar, Adam C., Bravo, Veronica, Leone, Gustavo, Houghton, Peter, Hideg, Kálmán, Kuppusamy, Periannan, Cohn, David E., Selvendiran, Karuppaiyah
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286190/
https://ncbi.nlm.nih.gov/pubmed/24590057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2433
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