HO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer

STAT3 is well corroborated preclinically as a cancer therapeutic target, but tractable translational strategies for its blockade by small molecule inhibitors have remained elusive. In this study, we report the development of a novel class of bifunctional STAT3 inhibitors, based on conjugation of a d...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Rath, Kellie S., Naidu, Shan K., Lata, Pushpa, Bid, Hemant K., Rivera, Brian K., McCann, Georgia A., Tierney, Brent J., ElNaggar, Adam C., Bravo, Veronica, Leone, Gustavo, Houghton, Peter, Hideg, Kálmán, Kuppusamy, Periannan, Cohn, David E., Selvendiran, Karuppaiyah
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286190/
https://ncbi.nlm.nih.gov/pubmed/24590057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2433
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