Tau Reduction Diminishes Spatial Learning and Memory Deficits after Mild Repetitive Traumatic Brain Injury in Mice

OBJECTIVE: Because reduction of the microtubule-associated protein Tau has beneficial effects in mouse models of Alzheimer's disease and epilepsy, we wanted to determine whether this strategy can also improve the outcome of mild traumatic brain injury (TBI). METHODS: We adapted a mild frontal i...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cheng, Jason S., Craft, Ryan, Yu, Gui-Qiu, Ho, Kaitlyn, Wang, Xin, Mohan, Geetha, Mangnitsky, Sergey, Ponnusamy, Ravikumar, Mucke, Lennart
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281043/
https://ncbi.nlm.nih.gov/pubmed/25551452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115765
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