Tau Reduction Diminishes Spatial Learning and Memory Deficits after Mild Repetitive Traumatic Brain Injury in Mice

OBJECTIVE: Because reduction of the microtubule-associated protein Tau has beneficial effects in mouse models of Alzheimer's disease and epilepsy, we wanted to determine whether this strategy can also improve the outcome of mild traumatic brain injury (TBI). METHODS: We adapted a mild frontal i...

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Publicat a:PLoS One
Autors principals: Cheng, Jason S., Craft, Ryan, Yu, Gui-Qiu, Ho, Kaitlyn, Wang, Xin, Mohan, Geetha, Mangnitsky, Sergey, Ponnusamy, Ravikumar, Mucke, Lennart
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281043/
https://ncbi.nlm.nih.gov/pubmed/25551452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115765
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