Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

Axonal transport deficits in Alzheimer’s disease (AD) are attributed to amyloid β (Aβ) peptides and pathological forms of the microtubule-associated protein tau. Genetic ablation of tau prevents neuronal overexcitation and axonal transport deficits caused by recombinant Aβ oligomers. Relevance of th...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Vossel, Keith A., Xu, Jordan C., Fomenko, Vira, Miyamoto, Takashi, Suberbielle, Elsa, Knox, Joseph A., Ho, Kaitlyn, Kim, Daniel H., Yu, Gui-Qiu, Mucke, Lennart
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427789/
https://ncbi.nlm.nih.gov/pubmed/25963821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201407065
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