Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport

Amyloid-β (Aβ) peptides, derived from the amyloid precursor protein, and the microtubule-associated protein tau are key pathogenic factors in Alzheimer’s disease (AD). How exactly they impair cognitive functions is unknown. Here we assessed the effects of Aβ and tau on axonal transport of mitochondr...

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Detalhes bibliográficos
Main Authors: Vossel, Keith A., Zhang, Kai, Brodbeck, Jens, Daub, Aaron C., Sharma, Punita, Finkbeiner, Steven, Cui, Bianxiao, Mucke, Lennart
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024010/
https://ncbi.nlm.nih.gov/pubmed/20829454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1194653
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