Tau Reduction Diminishes Spatial Learning and Memory Deficits after Mild Repetitive Traumatic Brain Injury in Mice

OBJECTIVE: Because reduction of the microtubule-associated protein Tau has beneficial effects in mouse models of Alzheimer's disease and epilepsy, we wanted to determine whether this strategy can also improve the outcome of mild traumatic brain injury (TBI). METHODS: We adapted a mild frontal i...

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Bibliographic Details
Published in:PLoS One
Main Authors: Cheng, Jason S., Craft, Ryan, Yu, Gui-Qiu, Ho, Kaitlyn, Wang, Xin, Mohan, Geetha, Mangnitsky, Sergey, Ponnusamy, Ravikumar, Mucke, Lennart
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281043/
https://ncbi.nlm.nih.gov/pubmed/25551452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115765
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