A peripherally selective diphenyl purine antagonist of the CB1 receptor

Antagonists of the CB1 receptor can be useful in the treatment of several diseases including obesity, diabetes, and liver disease. However, to date, the only clinically approved CB1 receptor antagonist, rimonabant, was withdrawn due to adverse CNS related side effects such as depression and suicidal...

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Bibliografske podrobnosti
izdano v:J Med Chem
Main Authors: Fulp, Alan, Bortoff, Katherine, Zhang, Yanan, Mathews, James, Snyder, Rodney, Fennell, Tim, Marusich, Julie A., Wiley, Jenny L., Seltzman, Herbert, Maitra, Rangan
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281022/
https://ncbi.nlm.nih.gov/pubmed/24041123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401129n
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