GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex

The androgen receptor (AR) is a key driver of prostate cancer (PC), even in the state of castration-resistant PC (CRPC) and frequently even after treatment with second-line hormonal therapies such as abiraterone and enzalutamide. The persistence of AR activity via both ligand-dependent and ligand-in...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: He, Bin, Lanz, Rainer B., Fiskus, Warren, Geng, Chuandong, Yi, Ping, Hartig, Sean M., Rajapakshe, Kimal, Shou, John, Wei, Liping, Shah, Shrijal S., Foley, Christopher, Chew, Sue Anne, Eedunuri, Vijay K., Bedoya, Diego J., Feng, Qin, Minami, Takashi, Mitsiades, Constantine S., Frolov, Anna, Weigel, Nancy L., Hilsenbeck, Susan G., Rosen, Daniel G., Palzkill, Timothy, Ittmann, Michael M., Song, Yongcheng, Coarfa, Cristian, O’Malley, Bert W., Mitsiades, Nicholas
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280633/
https://ncbi.nlm.nih.gov/pubmed/25489091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421415111
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