SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of cMYC oncoprotein

The E3 ubiquitin ligase adaptor speckle-type POZ protein (SPOP) is frequently dysregulated in prostate adenocarcinoma (PC), via either somatic mutations or mRNA downregulation, suggesting an important tumor suppressor function. To examine its physiologic role in the prostate epithelium in vivo, we g...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Oncogene
Autors principals: Geng, Chuandong, Kaochar, Salma, Li, Min, Rajapakshe, Kimal, Fiskus, Warren, Dong, Jianrong, Foley, Christopher, Dong, Boming, Zhang, Li, Kwon, Oh-Joon, Shah, Shrijal S., Bolaki, Menaka, Xin, Li, Ittmann, Michael, O’Malley, Bert W., Coarfa, Cristian, Mitsiades, Nicholas
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887163/
https://ncbi.nlm.nih.gov/pubmed/28414305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.80
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars