Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer

Somatic missense mutations in the substrate-binding pocket of the E3 ubiquitin ligase adaptor SPOP are present in up to 15% of human prostate adenocarcinomas (PC), but are rare in other malignancies suggesting a prostate-specific mechanism of action. SPOP promotes ubiquitination and degradation of s...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Geng, Chuandong, Rajapakshe, Kimal, Shah, Shrijal S., Shou, John, Eedunuri, Vijay Kumar, Foley, Christopher, Fiskus, Warren, Rajendran, Mahitha, Chew, Sue Anne, Zimmermann, Martin, Bond, Richard, He, Bin, Coarfa, Cristian, Mitsiades, Nicholas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209379/
https://ncbi.nlm.nih.gov/pubmed/25274033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0476
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak