Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

The p160 steroid receptor coactivators (SRCs) SRC-1, SRC-2 [nuclear receptor coactivator (NCOA)2], and SRC-3 [amplified in breast cancer 1 (AIB1)/NCOA3] are key pleiotropic “master regulators” of transcription factor activity necessary for cancer cell proliferation, survival, metabolism, and metasta...

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Autori principali: Geng, Chuandong, He, Bin, Xu, Limei, Barbieri, Christopher E., Eedunuri, Vijay Kumar, Chew, Sue Anne, Zimmermann, Martin, Bond, Richard, Shou, John, Li, Chao, Blattner, Mirjam, Lonard, David M., Demichelis, Francesca, Coarfa, Cristian, Rubin, Mark A., Zhou, Pengbo, O’Malley, Bert W., Mitsiades, Nicholas
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637757/
https://ncbi.nlm.nih.gov/pubmed/23559371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304502110
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