Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

The p160 steroid receptor coactivators (SRCs) SRC-1, SRC-2 [nuclear receptor coactivator (NCOA)2], and SRC-3 [amplified in breast cancer 1 (AIB1)/NCOA3] are key pleiotropic “master regulators” of transcription factor activity necessary for cancer cell proliferation, survival, metabolism, and metasta...

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Main Authors: Geng, Chuandong, He, Bin, Xu, Limei, Barbieri, Christopher E., Eedunuri, Vijay Kumar, Chew, Sue Anne, Zimmermann, Martin, Bond, Richard, Shou, John, Li, Chao, Blattner, Mirjam, Lonard, David M., Demichelis, Francesca, Coarfa, Cristian, Rubin, Mark A., Zhou, Pengbo, O’Malley, Bert W., Mitsiades, Nicholas
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637757/
https://ncbi.nlm.nih.gov/pubmed/23559371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304502110
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