Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer

Somatic missense mutations in the substrate-binding pocket of the E3 ubiquitin ligase adaptor SPOP are present in up to 15% of human prostate adenocarcinomas (PC), but are rare in other malignancies suggesting a prostate-specific mechanism of action. SPOP promotes ubiquitination and degradation of s...

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Autori principali: Geng, Chuandong, Rajapakshe, Kimal, Shah, Shrijal S., Shou, John, Eedunuri, Vijay Kumar, Foley, Christopher, Fiskus, Warren, Rajendran, Mahitha, Chew, Sue Anne, Zimmermann, Martin, Bond, Richard, He, Bin, Coarfa, Cristian, Mitsiades, Nicholas
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209379/
https://ncbi.nlm.nih.gov/pubmed/25274033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0476
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