Steric mechanism of auto-inhibitory regulation of specific and non-specific DNA binding by the ETS transcriptional repressor ETV6

DNA binding by the ETS transcriptional repressor ETV6 (or TEL) is auto-inhibited ~ 50-fold due to an α-helix that sterically blocks its ETS domain binding interface. Using NMR spectroscopy, we demonstrate that this marginally-stable helix is unfolded, and not displaced to a non-inhibitory position,...

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Udgivet i:J Mol Biol
Main Authors: De, Soumya, Chan, Anson C. K., Coyne, H. Jerome, Bhachech, Niraja, Hermsdorf, Ulrike, Okon, Mark, Murphy, Michael E. P., Graves, Barbara J., McIntosh, Lawrence P.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278593/
https://ncbi.nlm.nih.gov/pubmed/24333486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.11.031
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