Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B cell cytotoxicity in chronic lymphocytic leukemia

Selective cytotoxicity to cancer cells without compromising their normal counterparts pose a huge challenge for traditional drug design. Here we developed a tumor antigen targeted delivery of immunonanoparticle carrying a novel non-immunosuppressive FTY720 derivative OSU-2S with potent cytotoxicity...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Mani, Rajeswaran, Mao, Yicheng, Frissora, Frank W., Chiang, Chi-Ling, Wang, Jiang, Zhao, Yuan, Wu, Yun, Yu, Bo, Yan, Ribai, Mo, Xiaokui, Yu, Lianbo, Flynn, Joseph, Jones, Jeffrey, Andritsos, Leslie, Baskar, Sivasubramanian, Rader, Christoph, Phelps, Mitch A, Chen, Ching-Shih, Lee, Robert J., Byrd, John C., Lee, L. James, Muthusamy, Natarajan
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272672/
https://ncbi.nlm.nih.gov/pubmed/24947019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.199
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