ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in a CLL mouse model

Chronic lymphocytic leukemia (CLL) occurs in 2 major forms: aggressive and indolent. Low miR-29b expression in aggressive CLL is associated with poor prognosis. Indiscriminate miR-29b overexpression in the B-lineage of mice causes aberrance, thus warranting the need for selective introduction of miR...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Chiang, Chi-Ling, Goswami, Swagata, Frissora, Frank W., Xie, Zhiliang, Yan, Pearlly S., Bundschuh, Ralf, Walker, Logan A., Huang, Xiaomeng, Mani, Rajeswaran, Mo, Xiaokui M., Baskar, Sivasubramanian, Rader, Christoph, Phelps, Mitch A., Marcucci, Guido, Byrd, John C., Lee, L. James, Muthusamy, Natarajan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2019
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676131/
https://ncbi.nlm.nih.gov/pubmed/31151986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018882290
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