Intrinsic disorder drives N-terminal ubiquitination by Ube2w

Ubiquitination of the αN-terminus of protein substrates has been reported sporadically over the past twenty years. However the identity of an enzyme responsible for this unique ubiquitin (Ub) modification has only recently been elucidated. We show the ubiquitin-conjugating enzyme (E2) Ube2w employs...

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Библиографические подробности
Опубликовано в: :Nat Chem Biol
Главные авторы: Vittal, Vinayak, Shi, Lei, Wenzel, Dawn M., Scaglione, K. Matthew, Duncan, Emily D., Basrur, Venkatesha, Elenitoba-Johnson, Kojo S. J., Baker, David, Paulson, Henry L., Brzovic, Peter S., Klevit, Rachel E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270946/
https://ncbi.nlm.nih.gov/pubmed/25436519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1700
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