Programmable RNA recognition and cleavage by CRISPR/Cas9

The CRISPR-associated protein Cas9 is an RNA-guided DNA endonuclease that uses RNA:DNA complementarity to identify target sites for sequence-specific doublestranded DNA (dsDNA) cleavage(1-5). In its native context, Cas9 acts on DNA substrates exclusively because both binding and catalysis require re...

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Udgivet i:Nature
Main Authors: O’Connell, Mitchell R., Oakes, Benjamin L., Sternberg, Samuel H., East-Seletsky, Alexandra, Kaplan, Matias, Doudna, Jennifer A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268322/
https://ncbi.nlm.nih.gov/pubmed/25274302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13769
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