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Resampling the N9741 Trial to Compare Tumor Dynamic Versus Conventional End Points in Randomized Phase II Trials

PURPOSE: The optimal end point for randomized phase II trials of anticancer therapies remains controversial. We simulated phase II trials by resampling patients from N9741, a randomized phase III trial of chemotherapy regimens for metastatic colorectal cancer, and compared the power of various end p...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Sharma, Manish R., Gray, Elizabeth, Goldberg, Richard M., Sargent, Daniel J., Karrison, Theodore G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268251/
https://ncbi.nlm.nih.gov/pubmed/25349295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.57.2826
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