Clinical Utility of Metrics Based on Tumor Measurements in Phase II Trials to Predict Overall Survival Outcomes in Phase III Trials by Using Resampling Methods

PURPOSE: Phase II clinical trials inform go/no-go decisions for proceeding to phase III trials, and appropriate end points in phase II trials are critical for facilitating this decision. Phase II solid tumor trials have traditionally used end points such as tumor response defined by Response Evaluat...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: An, Ming-Wen, Han, Yu, Meyers, Jeffrey P., Bogaerts, Jan, Sargent, Daniel J., Mandrekar, Sumithra J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2015
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ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669590/
https://ncbi.nlm.nih.gov/pubmed/26503199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2015.60.8778
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