Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor suppressor activities

Notch activity regulates tumor biology in a context-dependent and complex manner. Notch may act as an oncogene or a tumor suppressor gene even within the same tumor type. Recently, Notch signaling has been implicated in cellular senescence. Yet, it remains unclear as to how cellular senescence check...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Kagawa, Shingo, Natsuizaka, Mitsuteru, Whelan, Kelly A., Facompre, Nicole, Naganuma, Seiji, Ohashi, Shinya, Kinugasa, Hideaki, Egloff, Ann Marie, Basu, Devraj, Gimotty, Phyllis A., Klein-Szanto, Andres J, Bass, Adam, Wong, Kwok-Kin, Diehl, J. Alan, Rustgi, Anil K., Nakagawa, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268095/
https://ncbi.nlm.nih.gov/pubmed/24931169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.169
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