Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive forms of squamous cell carcinomas. Common genetic lesions in ESCC include p53 mutations and EGFR overexpression, both of which have been implicated in negative regulation of Notch signaling. In addition, cyclin D1 is overexpress...

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Bibliographic Details
Main Authors: Naganuma, Seiji, Whelan, Kelly A, Natsuizaka, Mitsuteru, Kagawa, Shingo, Kinugasa, Hideaki, Chang, Sanders, Subramanian, Harry, Rhoades, Ben, Ohashi, Shinya, Itoh, Hiroshi, Herlyn, Meenhard, Diehl, J Alan, Gimotty, Phyllis A, Klein-Szanto, Andres J, Nakagawa, Hiroshi
Format: Artigo
Language:Inglês
Published: e-Century Publishing Corporation 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410579/
https://ncbi.nlm.nih.gov/pubmed/22860235
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