Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis

Insulin-like growth factor binding protein (IGFBP)-3 regulates cell proliferation and apoptosis in esophageal squamous cell carcinoma (ESCC) cells. We have investigated how the hypoxic tumor microenvironment in ESCC fosters the induction of IGFBP3. RNA interference experiments revealed that hypoxia-...

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Main Authors: Natsuizaka, Mitsuteru, Naganuma, Seiji, Kagawa, Shingo, Ohashi, Shinya, Ahmadi, Azal, Subramanian, Harry, Chang, Sanders, Nakagawa, Kei J., Ji, Xinjun, Liebhaber, Stephen A., Klein-Szanto, Andres J., Nakagawa, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2012
Teme:
Research Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360153/
https://ncbi.nlm.nih.gov/pubmed/22415309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-198598
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