Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis

Insulin-like growth factor binding protein (IGFBP)-3 regulates cell proliferation and apoptosis in esophageal squamous cell carcinoma (ESCC) cells. We have investigated how the hypoxic tumor microenvironment in ESCC fosters the induction of IGFBP3. RNA interference experiments revealed that hypoxia-...

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Détails bibliographiques
Auteurs principaux: Natsuizaka, Mitsuteru, Naganuma, Seiji, Kagawa, Shingo, Ohashi, Shinya, Ahmadi, Azal, Subramanian, Harry, Chang, Sanders, Nakagawa, Kei J., Ji, Xinjun, Liebhaber, Stephen A., Klein-Szanto, Andres J., Nakagawa, Hiroshi
Format: Artigo
Langue:Inglês
Publié: Federation of American Societies for Experimental Biology 2012
Sujets:
Research Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360153/
https://ncbi.nlm.nih.gov/pubmed/22415309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-198598
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