Insulin-like growth factor-binding protein-3 promotes transforming growth factor-β1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells

Insulin-like growth factor-binding protein (IGFBP)-3 is overexpressed frequently in esophageal squamous cell carcinoma. Yet, the role of IGFBP3 in esophageal tumor biology remains to be elucidated. We find that IGFBP3 facilitates transforming growth factor (TGF)-β1-mediated epithelial-to-mesenchymal...

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Détails bibliographiques
Auteurs principaux: Natsuizaka, Mitsuteru, Ohashi, Shinya, Wong, Gabrielle S., Ahmadi, Azal, Kalman, Ross A., Budo, Daniela, Klein-Szanto, Andres J., Herlyn, Meenhard, Diehl, J. Alan, Nakagawa, Hiroshi
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2010
Sujets:
Cancer Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915630/
https://ncbi.nlm.nih.gov/pubmed/20513670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgq108
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