Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma

Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor in squamous cell carcinomas (SCCs). However, Notch1 can be stochastically activated to promote carcinogenesis in murine mod...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Natsuizaka, Mitsuteru, Whelan, Kelly A., Kagawa, Shingo, Tanaka, Koji, Giroux, Veronique, Chandramouleeswaran, Prasanna M., Long, Apple, Sahu, Varun, Darling, Douglas S., Que, Jianwen, Yang, Yizeng, Katz, Jonathan P., Wileyto, E. Paul, Basu, Devraj, Kita, Yoshiaki, Natsugoe, Shoji, Naganuma, Seiji, Klein-Szanto, Andres J., Diehl, J. Alan, Bass, Adam J., Wong, Kwok-Kin, Rustgi, Anil K., Nakagawa, Hiroshi
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700926/
https://ncbi.nlm.nih.gov/pubmed/29170450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01500-9
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