Structural and mechanistic insights into the interaction between Pyk2 and Paxillin LD motifs

Proline-rich tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase (FAK) subfamily of cytoplasmic tyrosine kinases. The C-terminal Pyk2 focal adhesion-targeting (Pyk2-FAT) domain binds to paxillin, an adhesion molecule. Paxillin has five leucine-aspartate (LD) motifs (LD1–LD5). Here, we...

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Publicado en:J Mol Biol
Main Authors: Vanarotti, Murugendra S., Miller, Darcie J., Guibao, Cristina D., Nourse, Amanda, Zheng, Jie J.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267758/
https://ncbi.nlm.nih.gov/pubmed/25174335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.08.014
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