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Structural and mechanistic insights into the interaction between Pyk2 and Paxillin LD motifs
Proline-rich tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase (FAK) subfamily of cytoplasmic tyrosine kinases. The C-terminal Pyk2 focal adhesion-targeting (Pyk2-FAT) domain binds to paxillin, an adhesion molecule. Paxillin has five leucine-aspartate (LD) motifs (LD1–LD5). Here, we...
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| Publicat a: | J Mol Biol |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4267758/ https://ncbi.nlm.nih.gov/pubmed/25174335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.08.014 |
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