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Allelic Exclusion of TCR α-Chains upon Severe Restriction of Vα Repertoire
Development of thymocytes through the positive selection checkpoint requires the rearrangement and expression of a suitable T cell receptor (TCR) α-chain that can pair with the already-expressed β-chain to make a TCR that is selectable. That is, it must have sufficient affinity for self MHC-peptide...
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| Publié dans: | PLoS One |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4264757/ https://ncbi.nlm.nih.gov/pubmed/25500569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114320 |
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