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The γ-secretase complex: from structure to function

One of the most critical pathological features of Alzheimer’s disease (AD) is the accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain. Aβ is derived from β-amyloid precursor protein (APP) through sequential cleavage by β- and γ-secretases. γ-secretase is a hig...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Cell Neurosci
Prif Awduron: Zhang, Xian, Li, Yanfang, Xu, Huaxi, Zhang, Yun-wu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263104/
https://ncbi.nlm.nih.gov/pubmed/25565961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00427
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