Transcriptional Regulation of PEN-2, a Key Component of the γ-Secretase Complex, by CREB

Gamma-secretase, which is responsible for the intramembranous cleavage of Alzheimer's β-amyloid precursor protein (APP), the signaling receptor Notch, and many other substrates, is a multiprotein complex consisting of at least four components: presenilin (PS), nicastrin, APH-1, and PEN-2. Despi...

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Detalhes bibliográficos
Main Authors: Wang, Ruishan, Zhang, Yun-wu, Sun, Ping, Liu, Runzhong, Zhang, Xian, Zhang, Xue, Xia, Kun, Xia, Jiahui, Xu, Huaxi, Zhang, Zhuohua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367199/
https://ncbi.nlm.nih.gov/pubmed/16449647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.4.1347-1354.2006
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