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The γ-secretase complex: from structure to function
One of the most critical pathological features of Alzheimer’s disease (AD) is the accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain. Aβ is derived from β-amyloid precursor protein (APP) through sequential cleavage by β- and γ-secretases. γ-secretase is a hig...
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| Publicado en: | Front Cell Neurosci |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Frontiers Media S.A.
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4263104/ https://ncbi.nlm.nih.gov/pubmed/25565961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00427 |
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