Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2

Indoleamine 2,3-dioxygenases (IDOs) are tryptophan-catabolizing enzymes with immunomodulatory functions. However, the biological role of IDO2 and its relationship with IDO1 are unknown. To assess the relationship between IDO2 and IDO1, we investigated the effects of co-expression of human (h) IDO2 o...

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Dettagli Bibliografici
Pubblicato in:Exp Mol Med
Autori principali: Lee, Young-Kwan, Lee, Hoon Bok, Shin, Dong-Mi, Kang, Min Jueng, Yi, Eugene C, Noh, Seungjoo, Lee, Jaewoo, Lee, Chulbom, Min, Chang-Ki, Choi, Eun Young
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261913/
https://ncbi.nlm.nih.gov/pubmed/25394548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2014.69
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