Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1)

[Image: see text] Indoleamine-2,3-dioxygenase-1 (IDO1) has emerged as a target of significant interest to the field of cancer immunotherapy, as the upregulation of IDO1 in certain cancers has been linked to host immune evasion and poor prognosis for patients. In particular, IDO1 inhibition is of int...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: White, Catherine, McGowan, Meredeth A., Zhou, Hua, Sciammetta, Nunzio, Fradera, Xavier, Lim, Jongwon, Joshi, Elizabeth M., Andrews, Christine, Nickbarg, Elliott B., Cowley, Phillip, Trewick, Sarah, Augustin, Martin, von Köenig, Konstanze, Lesburg, Charles A., Otte, Karin, Knemeyer, Ian, Woo, Hyun, Yu, Wensheng, Cheng, Mangeng, Spacciapoli, Peter, Geda, Prasanthi, Song, Xuelei, Smotrov, Nadya, Curran, Patrick, Heo, Mee Ra, Abeywickrema, Pravien, Miller, J. Richard, Bennett, David Jonathan, Han, Yongxin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153270/
https://ncbi.nlm.nih.gov/pubmed/32292563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00010
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