Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors

[Image: see text] Indoleamine-2,3-dioxygenase-1 (IDO1) has emerged as an attractive target for cancer immunotherapy. An automated ligand identification system screen afforded the tetrahydroquinoline class of novel IDO1 inhibitors. Potency and pharmacokinetic (PK) were key issues with this class of c...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Li, Derun, Deng, Yongqi, Achab, Abdelghani, Bharathan, Indu, Hopkins, Brett Andrew, Yu, Wensheng, Zhang, Hongjun, Sanyal, Sulagna, Pu, Qinglin, Zhou, Hua, Liu, Kun, Lim, Jongwon, Fradera, Xavier, Lesburg, Charles A., Lammens, Alfred, Martinot, Theodore A., Cohen, Ryan D., Doty, Amy C., Ferguson, Heidi, Nickbarg, Elliott B., Cheng, Mangeng, Spacciapoli, Peter, Geda, Prasanthi, Song, Xuelei, Smotrov, Nadya, Abeywickrema, Pravien, Andrews, Christine, Chamberlin, Chad, Mabrouk, Omar, Curran, Patrick, Richards, Matthew, Saradjian, Peter, Miller, J. Richard, Knemeyer, Ian, Otte, Karin M., Vincent, Stella, Sciammetta, Nunzio, Pasternak, Alexander, Bennett, David Jonathan, Han, Yongxin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957919/
https://ncbi.nlm.nih.gov/pubmed/33738066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00525
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